LHRH Stimulation Test

LHRH stimulation test, also known as the GnRH stimulation test, is used in the evaluation of precocious puberty, a condition in which puberty begins earlier than normal. Here's how the test is typically conducted in the context of precocious puberty:

  1. Preparation: Before the test, the child may need to fast overnight, and it's essential to inform the healthcare provider about any medications the child is taking.
  2. Baseline Measurements: Initially, baseline measurements of gonadotropins, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are taken from a blood sample. Elevated baseline levels of LH and FSH can suggest central precocious puberty, where the onset of puberty is driven by premature activation of the hypothalamic-pituitary-gonadal axis.
  3. LHRH (GnRH) Administration: The child is then given a synthetic form of gonadotropin-releasing hormone (GnRH), typically through an injection. GnRH stimulates the release of LH and FSH from the pituitary gland.
  4. Monitoring: Blood samples are taken at regular intervals, usually 60 minutes and certain duration based on protocol used, after GnRH administration, to measure LH and FSH levels in response to the stimulation.
  5. Interpretation: The results of the test are interpreted based on the LH and FSH response to GnRH stimulation. In children with precocious puberty, a significant increase in LH and FSH levels after GnRH administration confirms the activation of the hypothalamic-pituitary-gonadal axis and supports the diagnosis of central precocious puberty.

The LHRH stimulation test helps to differentiate between central (or true) precocious puberty, where the premature activation of the hypothalamic-pituitary-gonadal axis is the underlying cause, and peripheral (or pseudo) precocious puberty, where the activation of puberty occurs independently of the hypothalamic-pituitary-gonadal axis. This test plays a crucial role in the diagnosis and management of precocious puberty, as it guides further evaluation and treatment decisions.

4790e0a3ad24860dd314c7ab7d8c5a0e_type-1-diabetes-children-clipart_420-420

Patient Education / FAQs

Topic 1

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

Topic 2

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

Topic 3

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.