HCG Stimulation Test

hCG stimulation test, also known as the human chorionic gonadotropin stimulation test, is a medical procedure primarily used to assess the function of the Leydig cells in the testes of males. It's used in the diagnosis and evaluation of disorders related to testosterone and dihydrotestosterone production. Here's how the test typically works:

  1. Preparation: Before the test, the individual may need to fast overnight, and it's essential to inform the healthcare provider about any medications the individual is taking.
  2. Baseline Measurements: Initially, baseline measurements of testosterone and DHT levels are taken from a blood sample.
  3. hCG Administration: The individual is then given a dose of human chorionic gonadotropin (hCG), typically through an injection daily for 3 continuous days. hCG is a hormone that mimics luteinizing hormone (LH) and stimulates the Leydig cells in the testes to produce testosterone.
  4. Monitoring: Blood samples are taken at regular intervals, usually 24 hour after last hCG administration, to measure testosterone and DHT levels in response to the stimulation.
  5. Interpretation: The results of the test are interpreted based on the testosterone and DHT response to hCG stimulation. In individuals with normal Leydig cell function, testosterone levels should rise significantly in response to hCG administration. A blunted or absent testosterone response may indicate dysfunction of the Leydig cells and impaired testosterone production.

The hCG stimulation test is commonly used in the evaluation of disorders of sexual development, such as hypogonadism (low testosterone levels) or delayed puberty, in males. It helps to differentiate between primary hypogonadism (testicular dysfunction) and secondary hypogonadism (due to problems with the hypothalamus or pituitary gland).

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